| Owen Wilson | .... | Lightning McQueen (Stimme) |
| Paul Newman | .... | Doc Hudson (Stimme) |
| Bonnie Hunt | .... | Sally Carrera (Stimme) |
| Larry the Cable Guy | .... | Mater (Stimme) |
| Cheech Marin | .... | Ramone (Stimme) |
| Tony Shalhoub | .... | Luigi (Stimme) |
| Guido Quaroni | .... | Guido (Stimme) |
| Jenifer Lewis | .... | Flo (Stimme) |
| Paul Dooley | .... | Sarge (Stimme) |
| Michael Wallis | .... | Sheriff (Stimme) |
| George Carlin | .... | Filmore (Stimme) |
| Katherine Helmond | .... | Lizzie (Stimme) |
| John Ratzenberger | .... | Mack (Stimme) |
| Joe Ranft | .... | Red (Stimme) |
| Michael Keaton | .... | Chick Hicks (Stimme) |
| Richard Petty | .... | The King (Stimme) |
| Jeremy Piven | .... | Harv (Stimme) |
| Bob Costas | .... | Bob Cutlass (Stimme) |
| Darrell Waltrip | .... | Darrell Cartrip (Stimme) |
| Richard Kind | .... | Van (Stimme) |
| Edie McClurg | .... | Minny (Stimme) |
| Humpy Wheeler | .... | Tex (Stimme) |
| Tom Magliozzi | .... | Rusty Rust-Eze (Stimme) |
| Ray Magliozzi | .... | Dusty Rust-Eze (Stimme) |
| Lynda Petty | .... | Mrs. The King (Stimme) |
| Andrew Stanton | .... | Fred (Stimme) |
| Dale Eranhardt, Jr. | .... | Junior (Stimme) |
| Michael Schumacher | .... | Michael Schumacher Ferrari (Stimme) |
| Jay Leno | .... | Jay Limo (Stimme) |
| Mario Andretti | .... | Mario Andretti (Stimme) |
| Sarah Clark | .... | Kori Turbowitz (Stimme) |
| Mike "No Name" Nelson | .... | Not Chuck (Stimme) |
| Joe Ranft | .... | Peterbilt (Stimme) |
| Jonas Rivera | .... | Boost (Stimme) |
| Lou Romano | .... | Snotrod (Stimme) |
| Adrian Ochoa | .... | Wingo (Stimme) |
| E. J. Holowicki | .... | DJ (Stimme) |
| Elissa Knight | .... | Tia (Stimme) |
| Lindsey Collins | .... | Mia (Stimme) |
| Larry Benton | .... | Motorhome Race Fan (Stimme) |
| Douglas "Mater" Keever | .... | Motorhome Race Fan (Stimme) |
| Tom Hanks | .... | Woody Car (Stimme) |
| Tim Allen | .... | Buzz Lightyear Car (Stimme) |
| John Ratzenberger | .... | Hamm Truck (Stimme) |
| Billy Crystal | .... | Mike Car (Stimme) |
| John Goodman | .... | Sullivan Truck (Stimme) |
| John Ratzenberger | .... | Abominable Snow Plow (Stimme) |
| Dave Foley | .... | Flik Car (Stimme) |
| John Ratzenberger | .... | P.T. Flea Car (Stimme) |
| Jack Angel | .... | Additional Voice (Stimme) |
| Michael Bell | .... | Additional Voice (Stimme) |
| Bob Bergen | .... | Additional Voice (Stimme) |
| Susan Blu | .... | Additional Voice (Stimme) |
| Andrea Boerries | .... | Additional Voice (Stimme) |
| Marco Boerries | .... | Additional Voice (Stimme) |
| Rodger Bumpass | .... | Additional Voice (Stimme) |
| Torbin Xan Bullock | .... | Additional Voice (Stimme) |
| Richard Cawood | .... | Additional Voice (Stimme) |
| Scott Clark | .... | Additional Voice (Stimme) |
| Kathy Coates | .... | Additional Voice (Stimme) |
| John Cygan | .... | Additional Voice (Stimme) |
| Jennifer Darling | .... | Additional Voice (Stimme) |
| Paul Eiding | .... | Additional Voice (Stimme) |
| Bill Farmer | .... | Additional Voice (Stimme) |
| Brian Fee | .... | Additional Voice (Stimme) |
| Teresa Ganzel | .... | Additional Voice (Stimme) |
| Craig Good | .... | Additional Voice (Stimme) |
| Jess Harnell | .... | Additional Voice (Stimme) |
| Artie Kempner | .... | Additional Voice (Stimme) |
| Hooman Khalili | .... | Additional Voice (Stimme) |
| Sonoko Konishi | .... | Additional Voice (Stimme) |
| Erik Langley | .... | Additional Voice (Stimme) |
| Sherry Lynn | .... | Additional Voice (Stimme) |
| Danny Mann | .... | Additional Voice (Stimme) |
| Mickie T. McGowan | .... | Additional Voice (Stimme) |
| Laraine Newman | .... | Additional Voice (Stimme) |
| Teddy Newton | .... | Additional Voice (Stimme) |
| Colleen O'Shaughnessey | .... | Additional Voice (Stimme) |
| Bob Peterson | .... | Additional Voice (Stimme) |
| Steve Purcell | .... | Additional Voice (Stimme) |
| Jan Rabson | .... | Additional Voice (Stimme) |
| A. J. Riebli, III | .... | Additional Voice (Stimme) |
| Dan Scanlon | .... | Additional Voice (Stimme) |
| Stephen Schaffer | .... | Additional Voice (Stimme) |
| Ken Schretzmann | .... | Additional Voice (Stimme) |
| Bob Scott | .... | Additional Voice (Stimme) |
| Matt Staudt | .... | Additional Voice (Stimme) |
| Jay Ward | .... | Additional Voice (Stimme) |
| Jim Ward | .... | Additional Voice (Stimme) |
| Colette Whitaker | .... | Additional Voice (Stimme) |